Which factor is known to inhibit the release of ADH?

The release of Antidiuretic Hormone (ADH), also known as vasopressin, is primarily regulated by the osmotic pressure of the blood and the hydration status of the body. ADH is responsible for water reabsorption in the kidneys, particularly in the collecting ducts, helping to concentrate the urine and reduce water loss when the body is dehydrated or when blood osmolarity is high.

Low solute concentration in the blood indicates that there is ample water relative to solutes. In this state, the body does not need to conserve water, which leads to a natural inhibition of ADH release. When blood osmolarity is low (reflecting low solute concentration), the hypothalamus signals the pituitary gland to decrease the secretion of ADH, allowing the kidneys to excrete more dilute urine and reduce fluid retention.

Conversely, high blood sodium levels, dehydration, and increased blood osmolarity would typically trigger an increase in ADH release in order to conserve water and restore balance. Therefore, low solute concentration clearly is a factor that inhibits the release of ADH, making it the correct choice in this context.